Tag Archives: Cannabis

Cannabis

What is Epidolex 

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Epidolex is a medicine that’s orally used to help with seizures. It’s got large numbers of CBD in it, with FDA-approved trials that demonstrate the efficacy of this drug. This does come from the same company that offers Sativex, which is a concoction that uses both THC and CBD, but with Epidolex, it comes with 100 mL of a solution, and up to 10,000 mg of CBD within it.  

This is something that’s used for those with neurological conditions, including seizures, and it’s something that a lot of people do use with young children, especially those who have Dravet syndrome and Lennox Gastraut syndrome.  This is something that is used to combat various conditions. 

When was it approved 

The FDA decided to approve this on June 25, 2018, and it’s something that was done because cannabis does offer great federal authority that’s there, and with more and more studies being conducted on this, various other formulations of cannabis are right there, and it’s something that’s FDA-approved, which opens the door for more approvals down the line. 

This is something that’s used to help with seizure treatment, and it offered new and bThis also does offer a chance for better, more active developments on different ingredients and other medical therapies to help with drug development. 

How it Works 

This basically uses CBD in order to target specifically the receptors that have something to do with epilepsy. With many products especially THC working together to help with the endocannabinoid system, which is a regulator that helps with CBD universally, this binds directly to a ton of the receptors which specifically make up this system and is used to balance out neurotransmitters on various other sites. 

This is something that combats seizures by helping with the controlling of the glutamate and the GABA neurotransmitters. This does create icons which are positively charged, and it does cause the neurons to be negatively charged as well, and it helps to create this sort of state as well through the utilization of this this. 

When these rest, they usually are a specific charge, but when they’re suddenly enacted, you do need to also look at the electron pulses that push all of this out. It causes a gap in the chemicals that are between the neurons, and the receptors work on these neighboring cells, depending upon the neurotransmitters which are released here. 

How it fights seizures 

How does it work? Well, it’s because of the properties of CBD and their benefits. It does bind directly to the TRPV-1 receptors, which do modulate seizures, and ramps up the calcium and glutamate releases. This does get activated by CBD as well. It also plays a major role in the disease and the release of it, causing influxes of neurons when it does get activated. It also works directly onto your serotonin receptors too in order to combat this, but researchers are still looking to underpin the actual state of these molecules here. 

It also works directly on the opioid receptors, and it does block them when there are large concentrations of this. It also has found that it works directly with a receptor called GPR55, and it works to properly modulate all of this, and the CBD does bind directly to the receptors there. There are some side effects, including the following when you take this: 

  • Drowsiness 
  • Lowered appetite 
  • Fatigue 
  • Malaise 
  • Rashes 
  • Insomnia 
  • Drug interactions 
  • Infections 
  • Insomnia 

These are the most common receptors, and you can always speak a professional to see if it’s right for you. 

All About Cannabis Flavonoids 

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To date, researchers have found over 480 different compounds within the cannabis plant, mostly terpenes, cannabinoids, and flavonoids. While cannabinoids and terpenes have grown in popularity, flavonoids are not discussed as much. 

Here, we’ll go over what the therapeutic effects are of this, and also why it’s something to look at if you’re trying to enhance your cannabis experience, in order to make t the best that it can be. 

What are They 

Simply put, flavonoids are considered phytonutrients that are found in all veggies and fruits and is responsible for the color of the fruits and veggies too. 

They do help flowers get pollinators, or also to protect the plant from UV ray damage, or disease and pests too! 

There are over 6000 differ kinds of flavonoids out there and some are even unique to different plants as well. 

For example, cannabis plants also contain flavonoids that are found nowhere else, and these are called cannanflavens. 

They are responsible for the colors that you see in the cannabis plant. For example, those that are a rich purple color have a lot of anthocyanins and anthoxanthins in it. 

Flavonoids also may offer different benefits too, including reducing inflammation, cancer, anti-inflammatory, and other effects that offer neuroprotection too. 

The entourage Effect 

Right now, most to the research done on this is mostly based on what’s called the entourage effect. This is the claim that each of these compounds are able to work together, to create the best therapeutic along with psychoactive results that they can. 

On their own, they’re only half as strong, but together, this creates something incredibly potent that a lot of people enjoy. 

Right now though, most of this I still in the research territory, and there is some different studies done to ensure that the cannabis flower changes, enhances the effects, and also the pathways in which this is done. 

The Future of Cannabis Research 

While there has been a lot of studies currently on terpenes, right now, flavonoids is something that is not studied enough.

For the most part, most of the efforts have been on the compounds, but we may see a sudden change in the way that the research goes from here on out. 

Right now, the current research is looking at how this might work to provide different pain relief. It also may be found in different green superfoods and plants, and it can provide a lot of beneficial results. 

Could it help with pain relief though? All the way back in 1986, a researcher named Marilyn Barrett was trying to isolate two major cannaflavins in order to ensure that there is enough potent effects. 

These usually are strong in it of itself, but she found that they could be more potent than those that are put out by aspirin. 

The problem though is that while there is research, it’s very small, with only .15% of studies done on cannabis being that subject. That means that a lot of marijuana needs to be looked at, and it does need to be consumed in heavy amounts in order to get the effects. 

Some research has worked around this to engineer these cannaflavins separately from the plant itself. Through successful identification of the gees in this, the researchers have been able to produce these as they’re isolated. 

They’ve bene used in other ways though in the form of cannabis alternatives for NSAIDs, and this might be something that a lot of people are looking at as an alternative to rely on, especially if they want to stop taking aspirin, Advil, and ibuprofen as well. 

The Worst Strains for Anxiety 

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Anxiety is not fun to deal with, and some people may use different cannabis strains to help with this. Some however, do the opposite effect. Here are the best strains to avoid if you suffer from anxiety. 

How Cannabis Can Affect Anxiety in a Bad Way 

Cannabis strains have different types of effects. Some are used to reduce the feelings of anxiety, while others may make it worse. There are a few different factors that cause this to create this. CBD is usually good for quelling anxiety, and lower dosages can be stimulating, but bigger dosages can also cause a more sedating result. 

THC also plays a role in this. In small doses, it can make you feel good, but for those who are easily susceptible to anxiety, it can make you more anxious. Low doses usually reduce it, while higher dosages create this. 

THC is also good for those who have anxiety if the terpenes fit this. Those that have a sedative effect usually are better. It doesn’t matter all that much whether it’s an indica or a sativa, but more along the lines of what the terpenes are, and the THC content that’s in there. It can make the anxiety worse depending on the types of strains that are there. 

The Worst Strains if You Have anxiety 

Here are some of the worst strains to have if you are prone to anxiety, especially with smoking. The first is Jack the ripper. It’s energizing, but it’s something best avoided if you suffer from anxiety. This is because it’s high in THC, and it can make you paranoid, disoriented, and also super anxious due to the THC that’s within this. Some people have mentioned though that if you take this in a low dose, it can mitigate the effects. 

The second one, is girl scout cookies, and this is one that’s dominant in indica, and gives you a head rush. It does, however, make it harder for people who are anxious to feel comfortable, as this can have properties that may be anxiety-inducing for you. Some people, however, have reported that it does increase the chance for self-reflection. However, this can sometimes have the opposite effect for those who have anxiety. 

Trainwreck is another one. Aptly named a trainwreck, this is one that those who are anxiety-prone should avoid like the plague, especially in higher amounts. It does cause a head rush in most cases, and some people who have anxiety have reported that it can make it hard for them to exist in some cases. 

Alaskan Thunderfuck is another one that’s good for people who like the head rush, but for people with anxiety, it can make things much worse. It can cause feelings of paranoia, and it can cause you to have a high that’s inquisitive and thought provoking. 

Then there is green crack, which is one that’s energizing, and is great for forming a daily routine and minding your own business, and also works to provide euphoria and productivity. However, it as well also has a high THC content to it, and the CBD in this is very low, so if you have a high amount of it, there is a chance that it can cause anxiety, so keep that in mind. 

Finally, you’ve got a tangerine dream, which is great for those who want to be creative, but for the anxiety-prone, it can cause thoughts to be racing, jitters, and is bad for managing anxiety. 

Try to avoid these strains or take them in small doses if you do suffer from anxiety for your own wellness and benefits.